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Prostate calcifications, often referred to as prostatic stones, are a prevalent concern among men, particularly those in their later years. These mineral deposits can be a source of considerable discomfort, manifesting as pain and urinary dysfunction. Fortunately, the medical community has developed a range of effective strategies to combat this condition, encompassing both pharmacological interventions and physiotherapeutic modalities. This article aims to provide an in-depth exploration of each medication and treatment approach that has demonstrated efficacy in dissolving and eliminating prostate calcifications.
Lidase
Lidase, a proteolytic enzyme, possesses the remarkable ability to break down protein structures. When administered in the prostatic region, Lidase facilitates the softening and dissolution of calcifications while simultaneously enhancing microcirculation within the glandular tissues.
This pharmaceutical agent is typically available as a lyophilizate (powder) that requires reconstitution with physiological saline immediately prior to use. To prepare the solution, the contents of a Lidase vial (64 units) should be diluted in 2-5 ml of 0.9% sterile water. The resulting mixture is then drawn into a syringe and introduced into the rectum via an enema apparatus following thorough bowel cleansing. Post-administration, patients are advised to assume a prone position.
The recommended regimen involves daily or alternate-day treatments for a duration of 10-15 days. To maximize therapeutic efficacy, it is advisable to retain the solution in the rectum for a minimum of 30-40 minutes, ideally until complete absorption occurs. For optimal results, consider repeating the treatment course after a 1-2 month interval.
Caution: Lidase may induce prostatic edema as an allergic response. Should symptoms worsen, reduce the dosage to half an ampoule and administer every other day. To mitigate edema and enhance enzyme penetration, consider adding 5-10 drops of an antihistamine such as cetirizine to the enema solution.
Dimexide
Dimexide (dimethyl sulfoxide) is a unique compound boasting anti-inflammatory, analgesic, and penetrative properties. When introduced rectally, Dimexide serves as an excellent vehicle for other medications (such as Lidase), facilitating their direct delivery to the prostate and amplifying their therapeutic effects.
To prepare the solution, dilute Dimexide with distilled water to achieve a 20-30% concentration. Administer 50-100 ml of this preparation rectally via enema following thorough bowel cleansing. The treatment should be performed daily for 10-15 days. Begin with a dosage of 1 drop of 100% solution per 50-100 ml and gradually increase to 6 drops. If adverse effects occur at higher concentrations, reduce the dose accordingly. Treatment can be temporarily suspended and resumed later if necessary.
For enhanced efficacy, other agents such as Lidase or Trilon B can be incorporated into the Dimexide solution. In such cases, prepare the Dimexide solution first, then add the desired quantity of additional medications.
Caution: Some patients may experience side effects such as dizziness, cardiac discomfort, arrhythmias, nausea, general weakness, and malaise when using Dimexide. If these symptoms occur, reduce the dosage to 1 drop of the preparation every 3 days.
Trilon B
Trilon B (disodium ethylenediaminetetraacetic acid) functions as a chelating agent, binding calcium ions and facilitating their elimination from the body. When administered rectally, Trilon B aids in dissolving prostate calcifications and inhibits the formation of new deposits.
To prepare the solution, dissolve 5-10 g of Trilon B powder in 100 ml of warm, boiled water. Administer the resulting mixture rectally via enema following thorough bowel cleansing. Perform this procedure daily for 10-15 days. For optimal results, retain the solution in the rectum for at least 20-30 minutes.
Monitor your well-being closely. If adverse effects occur, discontinue use and consider reintroducing the treatment at a 50% reduced dosage after a suitable interval.
It's worth noting that recipes for preparing Trilon B suppositories can be found online for those who prefer this administration method.
Longidaza
Longidaza is a conjugate of the enzyme hyaluronidase with a high-molecular-weight carrier. When introduced to the prostatic region, Longidaza facilitates the softening and dissolution of calcifications while enhancing the penetration of other medications into the glandular tissues.
This medication is available in suppository form, with each unit containing 3000 IU of longidaza. Insert the suppositories rectally following natural bowel evacuation or after an enema. Administer once daily before bedtime for a duration of 10-15 days. For maximal benefit, consider repeating the treatment course after a 3-6 month interval.
Extracorporeal shock wave therapy (ESWT)
ESWT represents a cutting-edge treatment modality that employs high-intensity acoustic waves to fragment prostate calcifications. This outpatient procedure does not require anesthesia.
During an ESWT session, the patient lies on an examination table while the practitioner applies a specialized applicator to the perineal area. This device generates shock waves that are focused on the prostatic region, effectively breaking down calcifications into smaller fragments that can be naturally expelled from the body.
A typical ESWT session lasts 20-30 minutes. The standard treatment protocol consists of 5-7 procedures spaced 5-7 days apart. To consolidate the therapeutic benefits, it is advisable to repeat the treatment course after a 3-6 month interval.
Conclusion
Prostate calcifications can significantly impair a man's quality of life, causing pain, discomfort, and urinary difficulties. However, modern medicine offers a diverse arsenal of tools to combat this condition effectively.
Medications such as Lidase, Dimexide, Trilon B, and Longidaza, when administered rectally, have demonstrated efficacy in softening and dissolving prostatic stones. Additionally, Extracorporeal Shock Wave Therapy has shown promising results in fragmenting calcifications, facilitating their natural elimination from the body.
It is crucial to emphasize that before initiating any treatment regimen, consultation with a urologist is imperative. Only a qualified specialist can devise an optimal therapeutic strategy tailored to the individual patient's needs and the specific stage of the condition.
Avoid prostate massage in the presence of calcifications, as this may exacerbate the condition.
For optimal outcomes, consider combining ESWT with the aforementioned pharmacological interventions.
After completing several treatment courses, it is advisable to undergo a follow-up transrectal ultrasound (TRUS) examination using the same equipment as the initial assessment. Compare the dimensions of the calcifications to evaluate treatment efficacy. If a reduction in size is observed, continue with the prescribed treatment regimen.
Timely and appropriate treatment can effectively eliminate prostate calcifications, improve genitourinary function, and enhance overall quality of life. The key lies in seeking prompt medical attention and adhering strictly to the prescribed treatment plan. Remember, your health is your most valuable asset – prioritize it accordingly.
Additional considerations
- Dietary Modifications: While not a direct treatment for prostate calcifications, adopting a diet rich in fruits, vegetables, and whole grains, and low in saturated fats may help reduce inflammation and support overall prostate health. Adequate hydration is also crucial to maintain proper urinary function and potentially aid in the prevention of new calcification formation.
- Exercise: Regular physical activity, particularly exercises that strengthen the pelvic floor muscles, may help improve blood flow to the prostate and support overall urinary health. Consult with your healthcare provider about appropriate exercises for your condition.
- Stress Management: Chronic stress can exacerbate various health conditions, including those affecting the prostate. Incorporating stress-reduction techniques such as meditation, deep breathing exercises, or yoga may complement your treatment regimen and improve overall well-being.
- Regular Check-ups: Even after successful treatment of prostate calcifications, it's important to maintain regular check-ups with your urologist. This allows for early detection of any recurrence or new issues, enabling prompt intervention if necessary.
- Combination Therapy: In some cases, your healthcare provider may recommend a combination of the treatments discussed above. For instance, ESWT might be used in conjunction with pharmacological interventions to achieve optimal results. Always follow your doctor's recommendations regarding treatment combinations and dosages.
- Patient Education: Understanding your condition and treatment options is crucial for successful management of prostate calcifications. Don't hesitate to ask your healthcare provider questions about your diagnosis, treatment plan, and expected outcomes. Being an informed patient can help you make better decisions about your health and improve treatment adherence.
- Lifestyle Modifications: Certain lifestyle factors, such as smoking and excessive alcohol consumption, may negatively impact prostate health. Consider quitting smoking and moderating alcohol intake as part of your overall health strategy.
- Alternative Therapies: While scientific evidence is limited, some men find relief from prostate-related symptoms through alternative therapies such as acupuncture or herbal supplements. Always consult with your healthcare provider before starting any alternative treatments to ensure they don't interfere with your primary treatment plan.
By taking a comprehensive approach to managing prostate calcifications — combining medical treatments with lifestyle modifications and regular monitoring — you can significantly improve your prognosis and quality of life. Remember, every individual's experience with prostate calcifications is unique, and what works best for one person may not be ideal for another. Work closely with your healthcare team to develop and adjust your treatment plan as needed, ensuring the best possible outcomes for your specific situation.